This is not a whole listing of feasible Uncomfortable side effects. When you notice other Unwanted effects not listed over, Call your doctor or pharmacist.
Will not abruptly discontinue Promethazine with Codeine Oral Resolution within a physically-dependent individual. Each time a patient who has been using Promethazine with Codeine Oral Answer regularly and could be physically dependent no longer requires therapy with Promethazine with Codeine Oral Solution, taper the dose gradually, by 25% to fifty% just about every 2 to four days, although checking very carefully for indications and symptoms of withdrawal.
Codeine has small plasma protein binding with about seven to twenty five% of codeine sure to plasma proteins. Codeine passes the blood brain barrier as well as the placental barrier. Little quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
When doctors prescribe codeine-containing prescription drugs, they ought to select the cheapest efficient dose for the shortest length of time and should inform their clients about these challenges as well as the indications of morphine overdose (see Safeguards - Nursing Moms).
Young children could possibly be notably sensitive towards the additive respiratory depressant consequences when promethazine is mixed with other respiratory depressants, like codeine.
Promethazine with Codeine Syrup, a clear purple syrup with odor of grape menthol, has promethazine hydrochloride six.
Narcotic analgesics, together with codeine, exert their primary results on the central nervous process and gastrointestinal tract. The analgesic outcomes of codeine are on account of its central action; having said that, the precise internet sites of action have not been identified, and also the mechanisms involved look like rather intricate.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals a lot less than 6 yrs of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory melancholy, and sometimes Loss of life, in pediatric people.
Promethazine is metabolized with the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites showing from the urine.
Promethazine hydrochloride occurs for a white to faint yellow, pretty much odorless, crystalline powder which gradually oxidizes and turns blue on extended publicity to air.
The treatment method of overdosage with promethazine and codeine is basically symptomatic and supportive. Only in instances of utmost overdosage or particular person sensitivity do crucial indications such as respiration, pulse, hypertension, temperature, and EKG must be monitored. Activated charcoal orally or by lavage could be offered, or sodium or magnesium sulfate orally to be a cathartic. Awareness needs to be offered on the reestablishment of satisfactory respiratory Trade by provision of a patent airway and establishment of assisted or controlled ventilation.
Drug interactions may perhaps modify how your remedies do the job or raise your possibility for significant Uncomfortable side effects. This doc isn't going to comprise all doable drug interactions.
Meticulously evaluate the dose utilizing a Particular measuring system/spoon. Do not use a household spoon as you may well not get the right dose.
Inform your health practitioner In case you are Expecting or Imagine you may be pregnant. Through pregnancy, this product just isn't encouraged. It may well damage an unborn little one. Speak to your health practitioner concerning the hazards more info and advantages of this medication. See also Warning part.